Dark Circles under your eyes making you look Older?
Important Facts about Dark Circles under Your Eyes
The skin around the eye is normally, very thin. It contains only delicate subcutaneous fatty tissue. As we age it becomes even thinner due to genetic disposition and external influences such as UV radiation. These factors play a significant part in the formation of dark circles, and puffiness. Both dark circles and puffiness are the result of poor circulation and blood retention. This leads to inflammation which increases the problem. If not corrected these conditions can lead to wrinkling and skin slackness.
See what people are saying about our Eye Serum for Reducing Dark Circles
When I was younger I was in an automobile accident that seriously injured my left eye. It left me with a sagging, drooping eye that looked disproportionate to my other eye. Using this product has not only dramatically lifted and smoothed my eye but it has entirely improved the way I look. I get lots of comments from my fellow workers and family that I look younger and more vibrant! I never thought it could ever happen. I am so excited and grateful! And after only 25 day’s!! Even my husband was surprised on how much improvement there was.
--Donda, Age 46
Donda, Age 46 after 25 days
American Academy of Dermatology (AAD).
With aging, all skin cells begin to produce excess amounts of free radicals--unstable oxygen molecules that, under ideal circumstances, are removed by naturally occurring antioxidants within the skin's cells. In aging skin cells, antioxidants are in short supply. The free radicals generated are left unchecked and cause damage to cell membranes, proteins, and DNA. These free radicals eventually break down a protein substance in connective tissue (collagen) and release chemicals that cause inflammation in the skin. It is a combination of these cellular and molecular events that leads to skin aging and the formation of wrinkles, the AAD says.
As we get older, two components of our skin--collagen and elastin--degenerate, setting the stage for the appearance of wrinkles, creases, folds, and furrows. The breakdown of these components, accelerated by sun exposure and gravity, results in the sagging skin of old age.
Our Revolutionary Skin Tightening Eye Serum Removes Your Dark Circles - GUARANTEED!
This SKIN TIGHTENING EYE SERUM is a concentrated anti-inflammatory complex of Vitamin C, A and B and age-reversing peptides that work especially well around the soft tissue of the eyes to even tone, reduce bags, puffiness, dark circles, wrinkles and crows feet. This Serum stimulates natural skin hydration and collagen production which firms and tones the skin around the eyes. (90 Day Supply)
Your Risk FREE, Lose Your Dark Circles Money Back Guarantee
We know you'll love your Younger Looking Skin, in fact we GUARANTEE it. Try Jeneuvia and if you're not 100% satisfied, send the bottles back and we'll issue you a refund (minus shipping and handling)
What set's Jeneuvia's Dark Circle Reduction Solution Apart?
Jeneuvia prides itself on being a New and Unique Anti Aging Solution. Some of the things that make Jeneuvia different are the fact that it's All Natural, and that the Peptides used in Jeneuvia are years ahead of any other Skin Care Solution.
Read about Peptides to find out why you MUST start using an Anti-Aging Solution that uses these Peptides
How Peptides Help Remove Dark Circles under your Eyes
PEPTIDES
The biggest breakthrough in anti-aging medicine in years are protein –like substances in our bodies called peptides and neuropeptides. Peptides are compounds consisting of two or more amino acids (the building blocks of proteins), chained together by what is called a peptide bond.
Neuropeptides are peptides released by neurons (brain cells) as intercellular messengers. Some neuropeptides function as neurotransmitters, and others function as hormones. Peptides and neuropeptides, like many substances in our bodies can work both for and against us. They were first known as endorphins.
Peptides can:
- increase production of collagen and elastin.
- Repair scars and wrinkles
- Increase circulation, resulting in breathtaking radiance and glow
- Experience rapid wound repair
- Develop a dewy, supple appearance to skin.
- Decreased inflammation
- Increased efficiency of metabolism, resulting in cellular repair.
- Repair of the skin
Scientists now know that neuropeptides, neurotransmitters, and hormones have a vast cellular communications system. The brain signals the thymus, the thymus gland signals the skin and the skin talks back to the brain. This trio controls every aspect of our bodies, using neuropeptides as their messengers.
Every messenger has a recipient for its message. These recipients are known as receptor sites.
The message delivered at the receptor site depends upon the particular neuropeptide, neurotransmitter, or hormone making the call.
While others use 1 peptide Jeneuvia uses 3 to create better results...
The Jeneuvia Wrinkle and Age Reversing Treatments use three different peptides that work together to address some of the main causes of aging:
free-radical damage Changes in fat content of skin Changes in skin collagen Dehydration Inflammation Degradation of the elastin polypeptides and Certain disorders in the packing of the lipid matrix of the skin.
The two primary wrinkle reducing peptides used in Jeneuvia Wrinkle and Age Reversing Treatment are ACETYL OCTAPEPTIDE-3 (a wrinkle reducing Peptide trade named SNAP-8 which is approximately 30% more active than its older parent peptide Argireline*) and PALMITOYL TRIPEPTIDE-5 (a wrinkle reducing Peptide trade named SYN-COLL).
These two peptides are among the newest generation of patented wrinkle reducing peptides. Details of the clinical studies involving each of these peptides may be read in this glossary of ingredients under the subject titles of SNAP 8 and SYN-COLL. The peptide manufacturers recommended effective % volume of ACETYL OCTAPEPTIDE-3 is 3%-10%. Clinical study results from the manufacturer were the results of a cream having 10% Acetyl Octapeptide-3.
Clinical studies show that:
ACETYL OCTAPEPTIDE-3 reduces the depth of wrinkles on the face caused by the contraction of muscles of facial expression, especially deep lines in the forehead and around the eyes.
ACETYL OCTAPEPTIDE-3 is a safer, cheaper and milder alternative to Botulinum Toxin, topically targeting the same wrinkle formation mechanism in a very different way.
The peptide manufacturers recommended effective % volume of PALMITOYL TRIPEPTIDE-5 is 1%-2.5%. The Clinical study results from the manufacturer showing the before and after photos (84 day test) were the result of using a cream with 2.5% Palmitoyl Tripeptide -5. Clinical studies show that:
PALMITOYL TRIPEPTIDE-5 actively removes any type of wrinkle
PALMITOYL TRIPEPTIDE-5 has in addition, skin firming and moisturizing properties
PALMITOYL TRIPEPTIDE-5 has been clinically proven to be safe and effective.
A third peptide, silk, is used in the Triple Peptide Facial Serum. Silk helps to prevent and repair the aging effects of the sun. Silk also reduces wrinkles by increasing skin hydration and stimulating natural collagen production. It tightens the skin and improves skin texture.
Jeneuvia Wrinkle and Age Reversing Treatment uses the above three peptides in combination to create a multiple faceted approach to addressing a fuller range of the causes of aging. Competitive Age reversing products normally use ONE peptide. Jeneuvia Wrinkle and Age Reversing Treatment uses THREE Peptides in a dosage of 25% volume. Three peptides, not just one, in volumes well above the volume necessary to produce positive results. This produces faster and more dramatic results.
Jeneuvia Wrinkle and Age Reversing Treatment represents a NEW and BROADER and natural approach to wrinkle and age reversing. Clinical studies prove and support ingredient effectiveness. Photos of people who have actually used Jeneuvia Wrinkle and Age Reversing Treatment demonstrates it effectiveness over a wide range of skin problems. We guarantee results for you. Order today and take advantage of Wholesale prices plus our free product incentive with free shipping over $100. We’ve taken the risk out of the decision to try our products. There is nothing to loose except what time has done to your skin.
More Info
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Vitamin Complex
Vitamins VITAMIN A (Retinyl Palmitate), Vitamin B3 (Niacinimide), Vitamin C (Ascorbic Acid) and N-Acetyl Glucosamine. are the major ingredients that make up Wallsburg farms Vitamin Complex, a major age reversing component of our Jeneuvia Wrinkle and Age-Reversing Treatment. Clinical studies supporting their individual effectiveness as age reversing ingredients is presented below:
Vitamin A (Retinyl Palmitate)
Vitamin A is the dominant vitamin of the skin because it has a fundamental role in the control of normal activities of skin cells. Vitamin A is of great importance in controlling normal activities of the DNA of the nucleus of the cell as well as the mitochondria. Current scientific research work is uncovering the complex means by which DNA maintains the normal activities of skin cells.
Vitamin A is normally found in the skin predominantly as retinyl palmitate, which is an ester of vitamin A. The ester is the most stable form of vitamin A. Retinyl palmitate is also a constituent of some topically-applied skin care products. After its absorption into the skin, retinyl palmitate is converted to Retinyl, and ultimately to retinoic acid (the active form of vitamin A present in Retin-A).
As early as 1935 it was pointed out that vitamin A deficiency probably developed in all areas that exposed to the sun. The reason for this is that vitamin A is extremely sensitive to sunlight and particularly to ultra violet light A (UVA). With the development of modern sunscreens we are not able to give sufficient protection of the skin from ultra violet A and so vitamin A is still damaged by exposure to light, even when a person is wearing a sun protection factor of 30 or 40.
In the 1930's it was postulated that skin exposed to sunlight aged faster than skin that was protected from sunlight. By 1955 it was discovered that the application of vitamin A as retinyl palmitate to aged skin rejuvenates the skin to a small degree. The test period at that time was a mere six weeks. Sigmund Berg showed that people who suffered bad sunburn could be improved by oral administration of vitamin A in high dosage. Today it is well recognised that the rejuvenation of skin can be achieved by applying vitamin A to the skin, but when one reads about the various types of vitamin A one may be confused as to which type of vitamin A to use on the skin…
Vitamin A should also be replaced every evening as a topical application to the skin to try and address the daily loss of vitamin A. Because we cannot prevent the damage to the vitamin A in the skin, it is essential to replace the vitamin A each day so that we do not gradually develop the signs of photoageing which are really also the signs of vitamin A deficiency of the skin.
By Dr. Des Fernandeshttp://www.environ.co.za/contents/articles/varieties_of_vitamin_a.htm
Vitamin B3 (Niacinimide)
* Topical application of N-acetyl glucosamine and niacinamide stimulated hyaluronan synthesis and elasticity of the skin
* N-acetyl glucosamine and niacinamide increases in collagen (procollagen-1)
* N-acetyl glucosamine and niacinamide reduced the appearance of facial fine lines and wrinkles, particularly in the eye area of the face
* N-acetyl glucosamine and niacinamide produced a reduction in melanin and an increase in collagen -- a key structural protein in skin.
* N-acetyl glucosamine and niacinamide produced improvement in hyperpigmentation and skin tone and a decrease in the size of age spots
* N-acetyl glucosamine and niacinamide significantly reduced facial hyperpigmentation in women aged 40-60 years
* Topical niacinamide reduces yellowing, wrinkling, red blotchiness, and hyperpigmented spots in aging facial skin.
* Topical application of niacinamide increases ceramide and free fatty acid levels in the skin, it prevent the skin from losing water content and it stimulates micro-circulation in the dermis.
* Niacinamide was shown in one small study to be more effective than petrolatum (Vaseline) for reducing water loss from skin and increasing its hydration levels.
* In ageing skin, topical application of niacinamide improves the surface structure, smoothes out wrinkles and inhibits photocarcinogenesis
Clinical Facial Study The clinical study was an 8-week double-blinded facial study of 35 to 60 year old women with moderate-severe fine lines and wrinkles. Facial moisturizer containing 2% N-acetyl glucosamine and 4% niacinamide was applied twice daily in a split face design, and compared to silicone-in-water vehicle control. At baseline, 4 and 8 weeks, digital facial images were obtained and analyzed for degree of facial fine lines and wrinkles, by expert grading
* In in vitro human skin cultures, topical application of N-acetyl glucosamine and niacinamide stimulated hyaluronan synthesis
* These treatments also led to an increase in collagen (procollagen-1) expression.
* Twice daily use of a facial moisturizer containing a combination of 2% N-acetyl glucosamine and 4% niacinamide for 4 to 8 weeks by women with moderate to severe fine and wrinkles reduced the appearance of facial fine lines and wrinkles, particularly in the eye area of the face.
* The in vitro hyaluronan results suggest that this effacement of fine lines and wrinkles is due at least in part to improved hydration of the skin.
The panel reviewed data from three studies involving the n-acetyl glucosamine /niacinamide formulation. Tissue studies showed a reduction in melanin and an increase in collagen -- a key structural protein in skin. Three double-blinded placebo-controlled clinical studies involving more than 200 subjects, including a study supervised by Dr. Kimball, showed improvement in hyperpigmentation and skin tone and a decrease in the size of age spots. The research is set to be presented in July at the "Academy '06" meeting of the American Academy of Dermatology (AAD), and was first presented at the AAD annual meeting in March 2006.
WHISTLER, B.C. -- A combination of 2% N-acetylglucosamine and 4% niacinamide significantly reduced facial hyperpigmentation in women aged 40-60 years, Dr. Alexa Kimball said at a dermatology symposium.
"About a decade's worth of our perception of age can be explained by pigmentation," said Dr. Kimball, director of the clinical unit for research trials in skin at Massachusetts General Hospital and Brigham and Women's Hospital in Boston. Dr. Kimball also serves as a consultant to Procter and Gamble, which funded the study
http://www.accessmylibrary.com/coms2/summary_0286-28984701_ITM
Topical N-Acetyl Glucosamine and Niacinamide Increases Hyaluronan
R. Osborne, Ph.D., L. A. Mullins, B.S. and L. R. Robinson, Ph.D. The Procter & Gamble Company, Cincinnati, Ohio USA
Introduction –
Hyaluronan (related to Hyaluronic Acid) is a mucopolysaccharide in the epidermis responsible for maintaining overall hydration and elasticity of the skin (1). A decline in epidermal hyaluronan content occurs during aging, contributing to decreased turgidity and increased wrinkle formation (2). N-Acetyl-glucosamine is a precursor of hyaluronan, and niacinamide is an essential co-factor of hyaluronan synthesis. In the current work, engineered human skin equivalent cultures were used to determine effects of topical N-acetyl glucosamine and niacinamide on hyaluronan and collagen expression, and for prediction of improved appearance of aging facial skin.
Objective
To evaluate the effects of n-acetyl glucosamine and niacinamide on expression of hyaluronan and collagen in human skin cell cultures in vitro. To confirm the in vitro responses via improved appearance of fine lines and wrinkles on facial skin in vivo. Hyaluronan and Collagen In Vitro Following topical treatment of skin equivalents with N-acetyl glucosamine, hyaluronan increased significantly and dose-responsively by up to 30% relative to vehicle control (Fig. 2). In addition to its role in skin hydration, hyaluronan, as a structural component of skin, plays a role in skin remodeling and wound healing, including contributing to the formation of a scaffolding along which fibroblasts can migrate (3). In response to N-acetyl-glucosamine, procollagen 1 increased dramatically and significantly in the skin equivalent models (Fig. 3). Niacinamide at 4% increased hyaluronan and procollagen 1 by 12 and 40%, respectively.
Fine Line and Wrinkle Improvements Women using a facial moisturizer containing a combination of 2% N-acetyl glucosamine and 4% niacinamide exhibited improvements in fine lines and wrinkles as compared to a vehicle product, with the greatest improvement at the earliest time point measured (4 weeks; Fig. 4), especially in the under-eye area of the face (Fig. 5).
Conclusion
* In in vitro human skin cultures, topical application of N-acetyl glucosamine and niacinamide stimulated hyaluronan synthesis.
* These treatments also led to an increase in collagen (procollagen-1) expression.
* Twice daily use of a facial moisturizer containing a combination of 2% N-acetyl glucosamine and 4% niacinamide for 4 to 8 weeks by women with moderate to severe fine and wrinkles reduced the appearance of facial fine lines and wrinkles, particularly in the eye area of the face.
* The in vitro hyaluronan results suggest that this effacement of fine lines and wrinkles is due at least in part to improved hydration of the skin.
References 1.Sayo T, Sakai S, Inoue S. Synergistic effect of N-acetylglucosamine and retinoids on hyaluronan production in human keratinocytes. Skin Pharmacol Physiol 2004; 17: 77-83. 2.Ghersetich I, Lotti T, Campanile G et al. Hyaluronic acid in cutaneous aging. Int J Dermatol 1994; 33: 119-22. 3.Weindl G, Schaller M, Schafer-Korting M, Korting HC. Hyaluronic acid in the treatment and prevention of skin diseases: molecular, biological, pharmaceutical and clinical aspects. Skin Pharmacol Physiol 2004; 17: 207-13.
http://www.pgbeautyscience.com/topical-n-acetyl-glucosamine-and-niacinamide-increase-hyaluronan.html
Topical niacinamide reduces yellowing, wrinkling, red blotchiness, and hyperpigmented spots in aging facial skin. ( Source: International Journal of Cosmetic Science, Volume 26, Number 5, October 2004 , pp. 231-238 Authors: Bissett, D. L.; Miyamoto, K.; Sun, P.; Li, J.; Berge, C. A.)
Topical application of niacinamide increases ceramide and free fatty acid levels in the skin, it prevent the skin from losing water content and it stimulates micro-circulation in the dermis. ( Source: British Journal of Dermatology, September 2000, pages 524?531; and Journal of Cosmetic Dermatology, April 2004, page 88)
Niacinamide was shown in one small study to be more effective than petrolatum (Vaseline) for reducing water loss from skin and increasing its hydration levels.( Source: International Journal of Dermatology, March 2005, pages 197-202)
Topical application of niacinamide has a stabilizing effect on epidermal barrier function, seen as a reduction in transepidermal water loss and an improvement in the moisture content of the horny layer. Niacinamide leads to an increase in protein synthesis (e.g. keratin), has a stimulating effect on ceramide synthesis, speeds up the differentiation of keratinocytes, and raises intracellular NADP levels. In ageing skin, topical application of niacinamide improves the surface structure, smoothes out wrinkles and inhibits photocarcinogenesis. ( Source: W Gehring (2004) Nicotinic acid/niacinamide and the skin Journal of Cosmetic Dermatology 3 (2), 88–93. )
Vitamin C (Ascorbic Acid)
Anti Aging Benefits of Vitamin C
How does topical Vitamin C compare and benefit the skin?
* Active in the skin up to 3 days (72 hours) after application.
* Anti-inflammatory response in the skin, prevents redness and inflammation even after sun exposure
* Topical application delivers 20 times more vitamin C than oral intake
* Free radical scavenger
* Maintains cellular integrity
* Vitamin C kills bacteria, natural wound healer, cuts inflammation – all related to acne.
Basically has two functions by
1. Stimulating collagen
2. Elastin
Collagen is the skin's firmness and elastin is the ability to retain its original shape. Vitamin C has the potential to enhance the density of dermal papillae, perhaps through the mechanism of angiogenesis. Topical vitamin C may have therapeutical effects for partial corrections of the regressive structural changes associated with the aging process". ( Source: Topically applied vitamin C increases the density of dermal papillae in aged human skin, Kirsten Sauermann, Sören Jaspers, Urte Koop, and Horst Wenck)
Vitamin C protects the cells of the skin ...
As a reducing agent, vitamin C can scavenge and destroy aggressive oxidizing agents and radicals in the skin: hydroperoxides and lipoperoxides, aggressors that are formed in the skin as a result of a wide range of environmental influences in everyday life, but particularly, intensive exposure to sunlight.
Vitamin C is capable of suppressing the pigmentation of the skin and decomposing melanin. In this way, it reduces the brown coloration of the skin, prevents the formation of freckles, birthmarks and senile keratosis, and can be used with good effect to whiten dark skin, or areas of dark skin. Sodium ascorbyl phosphate can be incorporated to provide the entire spectrum of positive effects of vitamin C. Preparations can be produced which, for example, protect against sunburn and the everyday effects of the environment, which whiten the skin, and which combat freckles or senile keratosis
Stability of ascorbyl phosphates in water:
- H. Takashima, H. Nomura, Y. Imai, H. Mima, Amer. Perfumer a. Cosmetics, 86, 29-36 (1971)
• Release of Vitamin C in the skin:
- H. Takashima, H. Nomura, Y. Imai, H. Mima, Amer.Perfumer a. Cosmetics, 86, 29-36 (1971)
- T. Sakamoto, M. Egawa, M. Tanaka, 19th IFSCC Congress, 2, 5-17 (1996)
• Protection against hydroxy radicals and lipoperoxides in the skin:
- T. Sakamoto, M. Egawa, M. Tanaka, 19th IFSCC
Congress, 2, 5-17 (1996)
- G.E. Erlemann: Vitamine in der Kosmetik; Seifen, Fette, Wachse, 110, 181-ff (1984)
• Protection against UV-related cell damage:
- T. Sakamoto, M. Egawa, M. Tanaka, 19th IFSCC
Congress, 2, 5-17 (1996)
- T. Kanatate et all; Cell. Biol. Res: 41, 561-567
(1996)
- S. Kobayashi, M. Takehana, S. Itoh; Photochem.
Photobiol. 64, 224-228 (1996)
• Promotion of collagen formation:
- R.I. Hata, H. Senoo, J. Cell. Physiol. 138, 8-16
(1989)
- M. Ono, Experimental Cell Research, 187, 309-
314 (1990)
- Geesin et al., Skin Pharmacol. 6, 65-71 (1993)
• Whitening of the skin with vitamin C derivatives:- Cosmetics a. Toiletries, 109, 100-102 (1994)
- R.Sacher, Technik u. Wissenschaft, 1, 122-123(1995)- H. Takashima, H. Nomura, Y. Imai, H. Mima, Amer.Perfumer a. Cosmetics, 86, 29-36 (1971)- T. Sakamoto, M. Egawa, M. Tanaka, 19th IFSCCCongress, 2, 5-17 (1996)
free-radical damage
